What is the standard first-line treatment for psychosis associated with substance withdrawal?

The standard first-line treatment for psychosis related to substance withdrawal is Haloperidol. This antipsychotic is often preferred due to its efficacy in rapidly controlling acute agitation and psychotic symptoms, which can occur during withdrawal from substances such as alcohol or benzodiazepines. Haloperidol works primarily as a dopamine antagonist, helping to mitigate the positive symptoms of psychosis.

In cases of substance withdrawal, the rapid onset of action and the ability to manage both hallucinations and agitation effectively make Haloperidol the go-to choice among healthcare providers. Other antipsychotics like Olanzapine, Risperidone, and Thioridazine may be used in various situations, but they do not have the same level of established use in the context of acute withdrawal. Olanzapine and Risperidone can also have sedative effects but may not act as quickly or effectively in managing severe withdrawal-related psychosis compared to Haloperidol.