What neurotransmitter does Wellbutrin affect in Cocaine addiction treatment?

Wellbutrin, also known as bupropion, primarily affects the neurotransmitter dopamine in the context of treating cocaine addiction. This medication is a norepinephrine-dopamine reuptake inhibitor (NDRI), which means it increases the concentration of dopamine in the synaptic cleft by inhibiting its reuptake. Cocaine addiction is associated with dysregulation of the brain's reward system, particularly involving dopamine pathways.

By enhancing dopaminergic activity, Wellbutrin can help alleviate cravings and withdrawal symptoms associated with cocaine use. This dopaminergic action is beneficial in re-establishing a more balanced neurochemical environment, which can support recovery efforts in individuals with cocaine addiction.

While Wellbutrin has some influence on norepinephrine as well, its primary therapeutic effect in this context emanates from its action on dopamine. The other neurotransmitters mentioned—5-HT (serotonin) and GABA—play different roles in mood regulation and anxiety, but they are not the primary targets of Wellbutrin's mechanism in the treatment of cocaine addiction.