What substance may be used in Cocaine addiction to increase the release of GABA?

Baclofen is a muscle relaxant and a gamma-aminobutyric acid (GABA) agonist that can influence the GABAergic system in the brain. In the context of cocaine addiction, Baclofen's role is particularly relevant because it can help to increase the release of GABA, an inhibitory neurotransmitter that can help modulate neurotransmission and reduce excitability in the central nervous system.

The mechanism by which Baclofen operates makes it useful in managing cravings and withdrawal symptoms associated with cocaine addiction. By enhancing GABA release, Baclofen may help create a calming effect, potentially countering the stimulant effects of cocaine and aiding in recovery efforts. This action aligns with the therapeutic strategies employed in addiction medicine, focusing on stabilizing neurotransmitter systems involved in addiction processes.

Other substances, such as Gabapentin and Lamotrigine, also have their own mechanisms affecting neurotransmission but do not primarily function to increase GABA release in the same manner as Baclofen. Serotonin is a neurotransmitter that plays various roles in mood regulation and is not directly used for increasing GABA release related to cocaine addiction treatment.