Which of the following sedative drugs can interact with Disulfiram?

Diazepam is known to interact with Disulfiram due to the way each medication is metabolized in the body. Disulfiram works by inhibiting the enzyme acetaldehyde dehydrogenase, leading to an accumulation of acetaldehyde when alcohol is consumed. While diazepam itself does not cause adverse reactions associated with alcohol, the interaction can manifest because Disulfiram can influence the metabolism of diazepam. This could lead to increased sedative effects, heightened risk of overdose, or respiratory depression due to the accumulation of the drug in the system.

Alprazolam and clonazepam may not historically have the same reported interactions with Disulfiram as diazepam does, though caution is advised with any benzodiazepine in patients treated with Disulfiram due to the overall nature of polypharmacy and patient variability. Buspirone, primarily used for anxiety, does not have a significant interaction with Disulfiram and does not contribute to the same risks. Thus, the specific metabolic interaction of diazepam with Disulfiram underscores why it is considered the correct answer.